Projects

kConFab Letter of Intent Submissions

Date	Investigators	Affiliation	Project Title
Nov 2009 Due December 2011 Full Application	Paul James, Gillian Mitchell, Alison Trainer, Judy Kirk, John Hopper; Melissa Southey, Stephen Fox, Ian Campbell	Peter MacCallum Cancer Centre, University of Melbourne, Westmead Hopital Sydney	Focus on pancreatic cancer
February 2010, due December 2011 Pilot application	Ashok Venkitaraman et al	Hutchison/MRC Research Centre, University of Cambridge, UK	Germline BRCA2 mutation carriers are at an increased risk of pancreatic ductal adenocarninoma.
April 2011, due December 2011 Full Application	Sunil Lakhani, Ernst Wolvetang, Chanel Smart, Jodi Saunus	University of Queensland Centre for Clinical Research (UQCCR)	Applying inducible pluripotent stem (iPS) cell technology to study mammary differentiation and breast cancer susceptibility.
JUne 2011, due December 2011 Full application	Chris Haiman, Tom Mack, John Hopper, Melissa Southey, Graham Giles	USC Keck School of Medicine, in Los Angeles, The University of Melbourne, The Cancer Council of Victoria, The Peter MacCallum Cancer Centre	A GWAS study involving women in kConFab who are known non-carriers of BRCA1 and BRCA2 mutations and are at the highest level of “polygenic” risk.
27th July 2011 Full Project	Simon Gayther	University of Southern California, USA	Linking risk associated SNPs for ovarian cancer to target genes in susceptibility regions
September 2011 Full Application	David Bowtell and the AOCS team	Peter MacCallum Cancer Centre	The role of CCNE1 amplification in breast cancer
November 2011, due May 2012 Full application	Andrea Bild	Department of Pharmacology and Toxicology, Utah University, Salt Lake City, USA	Do deregulated gene and protein expression levels predict breast cancer risk and reveal novel signaling pathways involved in familial breast cancer?
November 2011, due May 2012 Full Project	John Heath & John Hopper	The Children's Hospiotal and The University of Melbourne, Melbourne	Childhood cancer in families with BRCA1 or BRCA2 mutations ascertained via a high-risk breast cancer database.
December 2011 Full Project	John Hopper, Mary Beth Terry et al.	The University fo Melbourne	Expression of Interest: Genes, environment and breast cancer risk: the 15 year follow-up of the ProF-SC.
Jnauary 2012, full application due June 2012 Full Project	Goli Samimi	Cancer Research Program, Garvan Institute of Medical Research, NSW	Development of a Blood-Based DNA Methylation Assay for Screening of High Grade Serous Ovarian Cancer in High Risk Women
January 2012 application due June 2012 Full Project	Gail Risbridger, Patrick Humbert, Gillian Mitchell and Scott Williams.	Monash Medical Centre, Peter MacCallum Cancer Centre, Melbourne.	The Cancer of Prostate Translational Research In Victoria (CAPTIV) Collaboration.
January 2012, application due June 2012 Full application	Anthony Swerdlow	Institute of Cancer Research, UK	Collaborative international Genome-wide Association Study (GWAS) of genetic susceptibility to breast cancer in men

A pilot or full application must be made within 6 months of submitting the letter of intent. If more than six months has elapsed, a new letter of intent must be submitted prior to the full application.