kConFab Projects
Project NumberInvestigatorsAffiliationProject TitleStarting DatePublications
J. Kirk, C. Clarke, J. Leary Westmead Hospital Biological and genetic characteristics of normal breast in carriers Mar 1998 14
G. Chenevix-Trench , A. Spurdle, D. Easton, A Antoniou Queensland Institute of Medical Research (QIMR) Identification of BRCA1/2 modifier genes Aug 1998 4; 23; 40; 42; 43; 52; 70; 76; 82; 84; 85; 86; 87; 91; 96; 100; 109; 114; 115; 117; 121; 134; 136; 138; 139; 145; 147; 160; 162; 171; 172; 173; 174; 175; 176; 180; 181; 182; 190; 194; 195; 196; 197; 201; 202; 203; 221; 239; 247; 254; 255; 260; 266; 267; 281; 288; 291; 292; 293; 294; 295; 296; 297; 311; 313; 319; 321; 337
I. Hickie, G. Chenevix-Trench University of New South Wales Prospective psychoimmunological study of women from high-risk breast cancer families Jul 1999
Completed July 2007
G. Mann Westmead Institute for Medical Research Mapping and identification of novel breast cancer genes Aug 1999 6; 39; 68;
A. Whittemore Stanford University Modifiers of ovarian cancer risk in BRCA1/2 carriers Jun 1999 15
K. Tucker Prince of Wales Hospital Comparison of BRCA1-associated and sporadic ovarian adenocarcinoma Aug 1999 11; 16; 28; 242
C. Scott Peter MacCallum Cancer Centre Breast cancer penetrance in carriers of a BRCA1 or BRCA2 mutation enrolled in kConFaB Jul 2000 8; 9;
G. Chenevix-Trench, A. Spurdle, D. Easton, P. Oefner, G. Mann Queensland Institute of Medical Research Candidate gene analysis to search for BRCAx Sep 2000 3; 5; 19; 20; 25; 34; 44; 45; 46; 49; 54; 55; 56; 58; 69; 72; 74; 75; 76; 78; 80; 88; 94; 98; 102; 111; 122; 120; 123; 125; 128; 135; 141; 142; 155; 159; 168; 169; 170; 177; 194; 195; 196; 197; 198; 204; 205; 206; 214; 217; 218; 220; 224; 225; 228; 229; 230; 231; 234; 235; 243; 244; 246; 247; 250; 252; 256; 257; 258; 261; 262; 263; 264; 265; 270; 271; 275; 276; 278; 279; 280; 289; 298; 299; 300; 301; 302; 304; 305; 307; 308; 309; 310: 318; 322; 323; 324;326; 335; 336;341;342;343
I. Campbell Peter MacCallum Cancer Centre Mutation analysis of EP300 in BRCAx families Dec 2000 12
J. Leary Westmead Institute for Medical Research Frequency of large deletions in BRCA1 or BRCA2 Dec 2000 27;
K. Khanna Queensland Institute of Medical Research Identification of familial cases of breast cancer due to non-functional ATM or CHK2 kinase activity Feb 2001 41
G. Farshid, M. Cummings, R. Balleine, P. Waring Institute of Medical and Veterinary Science, Adelaise, South Australia Histology of Familial Breast Cancer Apr 2001 60;
D. Callen Women's and Children's Hospital Is T13 BRCA3? May 2001
K. Phillips Peter MacCallum Cancer Institute Clinical Outcome Project Jan 2004 14; 22; 38; 50; 53; 73; 105; 137; 215; 320; 330
G. Mann, G. Pupo Westmead Institute of Cancer Research Genes that influence susceptibility to both breast cancer and melanoma Jun 2001
P. Butow, I.Hickie, C. Tennant, K. Tucker, G. Berry, K. Phillips University of Sydney Psychosocial and psychoimmunological predictors of developing breast cancer in women from high risk families Jun 2001, March 2008 7; 13; 17; 51; 106; 130; 227; 236; 249; 251; 253; 272;
M. Jenkins, J. Hopper, K. Phillips, C. Scott University of Melbourne Environmental modifiers of breast cancer risk in carriers of a germline mutation in BRCA1 or BRCA2 Aug 2001, July 2007 32; 37; 61
I. Campbell, G. Lindeman, J. Visvader Peter MacCallum Cancer Institute Identification of BRCAx: analysis of genes interacting with the RING and BRCT domains of BRCA1 Dec 2001 57
A. Spurdle, M. Brown, G Chenevix-Trench, D Goldgar, S Lakhani, Catherine Clarke, S Grimmond, F Couch. Queensland Institute of Medical Research Functional Evaluation of BRCA1 and BRCA2 unclassified sequence variants and identification of critical pathogenic domains Feb 2003, October 2006 10; 21; 24; 30; 35; 47; 48; 63;64; 65; 110; 116; 153; 161 163; 183; 216; 219; 283; 284; 286; 312: 338
A. Whittemore Stanford University Genes for Hereditary Ovarian Cancer – are there others beside BRCA1 and BRCA2? Jul 2002
A. Whittemore Stanford University Breast cancer risk modifiers in BRCA carriers Jul 2002 210;
J. Kirk Westmead Hospital Pathological features of breast cancer in women with dominant-negative mutations in the ataxia telangiectasia mutated (ATM) gene Mar 2003 29
became 32/06-03
M. Brown UQ Adhesion molecules in BRCA1/2 tumours Dec 2002 26; 118;
G. Kay QIMR Immunofluorescence studies looking for hallmarks of X inactivation in breast cancer Feb 2003
M. Brown University of Queensland Transcriptional and post-transcriptional regulation of the BRCA1 gene Oct 2003, July 2006
M. Brown University of Queensland BRCA1 regulates epithelial morphogenesis and polarity and disruption of these functions contributes to BRCA1 mediated tumorigenesis Oct 2003 191
R. Anderson Peter MacCallum Cancer Institute Expression and localization of caveolin-1 in hereditary breast cancer Oct 2003
I. Campbell, G. Chenevix-Trench, J. Sambrook, P. Waring Peter MacCallum Cancer Institute Genome-wide study of loss of heterozygosity to identify breast cancer predisposition genes Jun 2004, October 2006
E. Lobb WA The experiences, attitudes, knowledge and psychological status of men from high risk breast cancer families Jun 2004 79
G. Chenevix-Trench, S. Grimmond, S. Lakhani QIMR Molecular Profiling of non-BRCA1/2 familial breast cancer Jun 2004; May 2007 112;
S. Tavtigian Utah Uniiversity Candidate breast cancer susceptibility genes: sequence variant discovery and differential expression analysis March 2008 81; 144;
G. Chenevix-Trench QIMR Is there a CpG island methylator phenotype in families with multiple cases of breast cancer Sep 2004; March 2006 97
D. Bowtell, R. van Laar PMCC Expression analysis in ovarian tumours from BRCA1/2 carriers Sep 2004
S. Fox University of Oxford The role of FOXP1 in familial breast cancer Nov 2004 83
S. Fox University of Oxford The role of hypoxia in familial breast cancer Nov 2004 89; 90; 154;
Not continued
N. Subramaniam QIMR Relationship between prognosticators of iron overload and breast cancer Jan 2005
A. Dobrovic PMCC Methylation of BRCA1 in mutation negative BRCA1-like tumours Feb 2005 62
A. Spurdle QIMR Altered X Inactivation Profiles in Breast and Ovarian Cancer May 2005 59;
R. Seitz AGI Comparison of BRCA mutation genotypes to immunohistochemically defined phentypes in breast carcinoma May 2005
G. Lindeman, J. Visvader, J. Sambrook The Walter and Eliza Hall Institute Breast stem cell markers and tumour stem cells in BRCA1, BRC2 and non-BRCA1/2 women Jun 2007 77; 294
J. Schildkraut, T. Rebbeck Duke University Genetic modifiers of BRCA1/2 (GEMS) Oct 2005 104;
D. Huntsman, J. Hopper, M. Southey BC Cancer Agency E-cadherin (CDH-1) a potential susceptibility gene for familial and early lobular breast cancer Feb 2006 149;
S.J. Dawson, J. Sambrook, Y. Antill, D. Goldgar, J. Hopper Peter MacCallum Cancer Centre Prostate cancer in hereditary breast cancer families Mar 2006 67;
P. Butow, C. Tennant, I. Campbell, D. Duffy, M. Price, B. Meiser University of Sydney Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Mar 2006
L. Hutschtscha, R. Reddel Children's Medical Research Institute Proliferation life span of LiF syndrome cells Apr 2006
R. Balleine Westmead Institute Insights into mechanisms of breast cancer pathogenesis from tissue pathology Apr 2006 95;
G. Chenevix-Trench, A. deFazio, D. Gertig QIMR Microarray-targeted candidate gene approach to finding ovarian cancer susceptibility genes. Aug 2006
J. Hopper, G. Mann, M. Jenkins, G. Byrnes, J. Dowty, C. Apicella, R. Milne, G. Dite, K. Byth Wilson, L. Baglietto, G. Severi, R. MacInnis, M. Southey, G. Giles University of Melbourne Penetrance and prevalence of BRCA1 and BRCA2 mutations Sep 2006
M. Tosi INSERM, France Evaluation of exon 1 and 2 duplications of BRCA2 Sep 2006
S. Lakhani, P. Simpson University of Queensland Lobular carcinomas in familial breast cancer Oct 2006
G. Chenevix-Trench, N. Wayte, D. Duffy, G. Suthers, S. Lakhani, M. Brown QIMR Searching for general cancer susceptibility genes Dec 2006
G. Chenevix-Trench QIMR Micro RNA profiles in breast and ovarian tumours from kConFaB Nov 2006
S. Lakhani, P. Simpson University of Queensland Exploring variation in the molecular genetic profiles of breast tumours from multiple-case families harbouring the same mutation. Feb 2007 113
G. Chenevix-Trench, S. Lakhani, P. Simpson QIMR Gene copy analysis of kConFab tumours. Mar 2007
A. Spurdle, Y. Antill, J. Young, D. Duffy, D. Goldgar, S. Lakhani, G. Mann, C. Stewart, P. Webb QIMR Breast-Endometrial cancer genetic predisposition. Apr 2007 127;
C. Clyne Prince Henry's Institute Regulation of aromatase by BRCA1 May 2007 71;
S. Neuhausen University of California, Irvine SNPs in the insulin-like growth factor (IGF) pathway and breast cancer risk. Apr 2007
M. Southey, J. Hopper, G. Mann, V. Hayes, M. Jenkins, G. Dite, G. Byrnes, L. Gurrin, J. Dowty, R. Milne, G. Giles, M. McCredie, D. Goldgar University of Melbourne Candidate genes for early-onset breast cancer Dec 2006
G. Chenevix-Trench, G. Lindeman, J. Visvader, S. Lakhani, I. Campbell QIMR, PMCC, WEHI and University of Queensland The role of GATA3 in familial breast tumours July 2007 93;
M. Southey, J. Hopper, M. Jenkins, G. Byrnes et al University of Melbourne Clarifying the contribution of BRIP1 and PALB2 in breast cancer risk July 2007 107; 108; 193; 207; 226; 233; 273;
M. Cossai, S. Lakhani University of Queensland Molecular analysis of low grade, triple negative breast carcinomas Aug 2007
S. Fox PMCC The role of FOXP3 and lymphoid subsets in familial breast cancer Oct 2007
R. Ward, M. Hitchens St Vincent's Hospital, Sydney The role of germ line epimutations of BRCA1 and BRCA2 in early onset and familial breast cancer. Oct 2007
S. Lakhani, G. Chenevix-Trench, G. Lindeman, J. Visvader University of Queensland Establishment of cancer cell lines and isolation of stem cells from metastases and pleural effusions Feb 2008
F. Couch, A. Antoniou, D. Easton Mayo Clinic A genome wide association study for breast cancer in BRCA1 mutation carriers Feb 2008 92
S. Fox, I. Haviv, I. Campbell PMCC MicroRNAs in familial basal-like breast cancer Feb 2008
Full project, completed
K. Phillips, J. Hopper, R. Milne Peter MacCallum Cancer Centre, The University of Melbourne Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers March 2008 101; 209;
Full project. Completed
K. Offit Memorial Sloan-Kettering Cancer Centre, New York An international study of BRCA2 penetrance June 2008 99
Full project. Completed
J. Byrne The Children's Hospital at Westmead, Sydney Quantitative IHC analysis of tumour protein D52 expression in breast tissue from patients at high risk of developing hereditary breast cancer. June 2008
Full project
G. Mitchell, G. Chenevix- Trench, A. Antoniou, D. Goldgar Peter MacCallum Cancer Centre Characterisation of the kConFab BRCAX cohort for selected breast cancer susceptibility loci and their effect on breast cancer risk in this cohort May 2008 287
T. Gonda, R. Ramsay, G.Francis UQ Diamantina Institute, Peter MacCallum Cancer Centre Confirmation and Analysis of MYB amplification in BRCA1-mutant breast tumours November 2008 140
S. Fox, G. Mitchell, D. Bolton, D. Clouston, I. Campbell, Peter MacCallum Cancer Centre , Austin Health, Melbourne Prostate cancer in carriers of mutations in the BRCA1, BRCA2 and BRCAX gene March 2009 151; 186; 222; 315
L. Walker, A. Spurdle QIMR, Royal Brisbane Hospital, Brisbane Investigation of copy number variants and familial breast cancer risk, and their interaction with rare BRCA1/2 sequence variants Feb 2009 340
Full application. Completed
T. Rebbeck University of Pennsylvania School of Medicine A CIMBA-wide study to estimate mutation- specific risks of breast and ovarian cancer in BRCA1/2 mutation carriers March 2009
Full project. Completed
J. Hopper, M. Southey, G. Giles, M. Jenkins, J. Dowty The University of Melbourne and The Cancer Council Victoria Phase 1 Breast Cancer Genome-Wide Association Study Using Early-Onset Cases April 2009
Full Project, completed July 2011
S. Fox, J. Benitez The Peter MacCallum Cancer Centre, Melbourne & The Spanish National Cancer Research Centre, Spain Mutation type and the basal like phenotype May 2009
C. Wakefield, B. Meiser, K. Tucker, G. Suthers The Prince of Wales Hospital, Sydney A pilot study of the Information Dissemination Preferences of Individuals with a Strong August 2009 148; 152; 185
M. Sherman, G. Chenevix- Trench, M. Garcia-Closas, J. Figueroa, P. Meltzer, S. Lakhani National Institute of Health (NIH) USA, QIMR Royal Brisbane Hospital, University of Queensland Identification of a common molecular signature for BRCA1-related and sporadic basal breast carcinoma: a pilot study towards refining the etiology of an aggressive tumor type August 2009
Full project application, completed
J. Flanagan Imperial College London Germline epigenetic alterations as a mechanism for carcinogenesis September 2009 157
Full application
I. Campbell, E. Thompson, G. Mitchell, J. Hopper Peter MacCallum Cancer Centre & The Universty of Melbourne Identification of BRCAX genes using whole exome sequencing October 2009 167; 187; 188; 189; 192
Full application completed
K. Bolton, P. Pharoah University of Cambridge BRCA1 & BRCA2 mutations and epithelial ovarian cancer prognosis October 2009 146 156; 240
Pilot application, Completed
G. Chenevix-Trench, J. Flanagan QIMR, Royal Brisbane Hospital & Imperial College London Patterns of methylation in BRCA1 & BRCA2 and sporadic ovarian cancer October 2009
G. Chenevix-Trench, N. Waddell QIMR, Royal Brisbane Hospital, Brisbane Identification of novel breast cancer predisposition genes using exome sequencing October 2009
Full application. Completed
G. Mitchell, G. Lindeman, G. Suthers Peter MacCallum Cancer Centre, Royal Melbourne Hospital, Women's and Children's Hospital, Adelaide Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls. The IMPACT Study November 2009 103; 119; 143
Full application. Completed
D. Thomas Peter MacCallum Cancer Centre Molecular genetics of sarcoma in hereditary breast cancer. November 2009 303
Full application. Completed
J. Bryne, R. Balleine The Children's Hospital at Westmead and Westmead Hospital, Sydney Quantitative immunohistochemical analysis of tumor protein D52 expression in breast tissue from patients at risk of developing hereditary breast cancer January 2010
Pilot application, Completed
S. Fox, M. McKay Peter MacCallum Cancer Centre & Canberra Hospital Cohesins and familial cancer January 2010 166
Full application, completed
K. Phillips, S.Harvey, J. Hopper, D. Goldgar, R. Milne, M. Friedlander, S. A. McLachlan PeterMac, The University of Melbourne, The University of Utah, USA, The Spanish Cancer Centre, Madrid, The Prince of Wales Hospital, Sydney Breast cancer risk in kConFab women known to be negative for a family mutation in BRCA1 or BRCA2. June 2010 131
Full project, completed
M. Cummings, J. Young, S. Lakhani, P. Simpson, M. Walsh UQ, Royal Brisbane & Womens Hospital and QIMR, Royal Brisbane Hospital, Brisbane. Immunohistochemical analysis of mismatch repair (MMR) proteins in familial and June 2010
Full Project. Completed
S. Fox, G. Mitchell, J. Holt Peter MacCallum Cancer Centre Melbourne & Tissue Genetics USA The identification of BRCA germline mutations using immunhistochemistry August 2010
Full project. Completed
D. Goldgar, M.Southey The University of Melbourne & Utah University USA An international meta analysis of genome wide linkage data in familial breast cancer. July 2010
K. K. Khanna, S. Lakhani, G. Chenevix-Trench QIMR, Royal Brisbane Hospital, Brisbane IHC analysis of DNA repair proteins in familial breast cancer September 2010
S. Hunter, I. Campbell, A. DeFazio Peter MacCallum Cancer Centre, Melbourne & Westmead Hospital, Sydney High resolution genome-wide SNP and copy number analysis of genetic September 2010 184; 223
Full application. Completed
S. MacGregor, G. Chenevix-Trench QIMR, Royal Brisbane Hospital, Brisbane Identifying markers of risk and outcome in breast cancer via efficient evaluation of epigenetic changes in non-cancerous tissue October 2010
Pilot Application, completed
J. Flanagan Imperial College London, UK Identification of novel breast cancer subgroups by DNA methylation September 2010
Full project. Completed
H. Shipman Clinical Epidemiology Interdisciplinary Research Group, Cardiff University, UK Consent for novel techniques in clinical practice and genetic research: Current experiences and looking ahead November 2010
S. Chanock, K. Bolton Cancer Epidemiology and Genetics, National Cancer Institute, USA Detecting Rare Variants for Ovarian Cancer in the 19p13 region. November 2010
Full application
M. Southey, D. Goldgar The University of Melbourne & The Utah University, USA A comprehensive approach to the genetics of breast cancer susceptibility in cases and families across the spectrum of risk October 2010 164; 165; 237
Full Application. Completed
J. Hopper, K. Phillips, G. Dite et al The University of Melbourne, The Peter MacCallum Cancer Centre, Melbourne Statistical analysis of an international 10 year prospective family study of gene-environment interactions on risk of female breast cancer. March 2011
Full Project. Completed
A. Trainer, P. James, G. Mitchell, I. Campbell, E. Thompson, S. Fox, J. Dowty, J. Hopper The Peter MacCallum Cancer Male Breast Cancer February 2011
A. Dunning, G. Chenevix-Trench Cambridge University, UK, QIMR, Brisbane Genetic Factors in Mean Telomere Length, Cancer Susceptibility April 2011
Full Application. Completed
J. Beesley, G. Chenevix-Trench Queensland Institute of Medical Research The TERT locus as a susceptibility gene for ovarian and breast cancer: genetic and functional evaluation April 2011 274
Full application. Completed
K. Phillips, I. Collins, J. Hopper, R. Milne Peter MacCallum Cancer Centre, The University of Melbourne and the National Spanish Cancer Institute. BRCA mutation status effect on age at menopause (BEAMS) May 2011 208; 285
Full Project. Completed
G. Chenevix-Trench, K. K. Khanna, D. Goldgar QIMR, Royal Brisbane Hospital and The University of Utah, USA Mutations in genes that modify epigenetic silencing in familial breast cancer June 2011
Full application
P. Simpson, G. Chenevix-Trench, M. Ragan QIMR, Royal Brisbane Hospital and the University of Queensland, A systems approach to defining therapeutic targets in breast cancer. June 2011
Full Project, completed
S. Fox, S. Lakhani, R. Balleine, D. Siddhartha Peter MacCallum Cancer Centre Melbourne, Westmead Hospital Sydney, University of Queensland, Brisbane Male Breast Cancer July 2011 200; 238; 245; 334
J. Mills, J. Pedersen TissuPath, Melbourne New biomarkers for prognosis in patients who have had a radical prostatectomy August 2011
L. Heiniger, M. Price, P. Butow The University of Sydney Distress and adaption among women from high risk breast cancer families September 2011
Kristy Brown Prince Henry's Institute, Melbourne AROMATASE REGULATION BY p53 AND HIF-1 IN OBESITY AND POST-MENOPAUSAL BREAST CANCER. January 2001
Ashok Venkitaraman and Ferdinandos Skoulidis MRC Cancer Cell Unit / Hutchison/MRC Research Centre, UK Molecular investigation into pancreatic cancer using resected human tissue April 2012
Full application
Anthony Swerdlow Sir Richard Doll Building, Institute of Cancer Research, UK Collaborative international Genome-wide Association Study (GWAS) of genetic susceptibility to breast cancer in men February 2012 198
Full application
Max Yan and Stephen Fox Prince of Wales Sydney and Peter MacCallum Cancer Centre Melbourne The role of miRNAs in familial breast cancer May 2012 268
Full application
Gail Risbridger, Renea Taylor, Scott Williams, Yual Haupt, Mark Frydenberg Monash medical Centre and Peter MacCallum Cancer Centre The Cancer of Prostate Translational Research In Victoria (CAPTIV) Collaboration. May 2012 232; 277; 317
Full Project
John Hopper, Kelly Phillips, Mary Beth Terry, Irene Andrulis, Ester John et al The University of Melbourne, The Peter MacCallum Cancer Centre, Melbourne, University of Columbia, Cancer Prevention institute of California, Cancer Care Ontario Genes, environment and breast cancer risk: the 15 year follow-up of the ProF-SC December 2012 282; 327
Elena Provenzano, Melissa Southey, Carmel Apicella, John Hopper, Gillian Dite Cambridge University and The University of Melbourne Using pathology to predict mutation status May 2013
Elizabeth Christie and David Bowtell The Peter MacCallum Cancer Centre Circulating TP53 mutations as a biomarker of high-grade serous ovarian cancer May 2013
Full project application
Melissa Southey et al The University fo Melbourne Is a proportion of the Missing Heritability of breast cancer due to heritable epigenetic variation? October 2013 241
Full application
Sherene Loi The Peter MacCallum Cancer Centre Understanding the Evolution of the Breast Cancer Genome and its Clinical Implications October 2013 314; 328
Full project application. Completed
Marcia Eisenberg,et al LabCorp USA Validation of BRCA mutations. October 2013
Full project application. Completed
Heidi Hilton, Christine Clarke et al Westmead Millennium Institute, NSW Cell type specificity of progesterone action in the normal human breast and in breast cancer October 2013
Full project application
Tissue Solutions, UK Tissue Solutions, UK Platinum resistance vs. senstivity in ovarian cancer patients December 2013
Full project application
Tissue Solutions UK Tissue Solutions UK Effect of chemotherapy on tumor microenvironment in breast cancer patients. February 2014
Full application
David Olmos, Elena Castro, Shahneen Shandu Spanish National Cancer Research Centre, Madrid, Spain and the Peter MacCallum Cancer Centre, Melbourne Integration of clinical, molecular and biological characteristics to define an aggressive subtype of sporadic prostate cancer based on germline BRCA mutated prostate cancer April 2014
Full project
Christian Singer and Sabine Danzinger Medical University of Vienna Phenotypic characterization of patients with BRCA1 and/or BRCA2-related breast cancer April 2014
Full Project. Completed
Mary Anne Young and Laura Forrest Peter MacCallum Cancer Centre, Melbourne Returning genetic test results. Exploring participants' experiences of making decisions about genetic testing after participating in kConFab, a genetic screening breast cancer research project. JUne 2014
Full project, completed
Melanie Price, Geoff Lindeman, Kelly Metcalfe, Carrie Snyder, Tuya Pal, Gareth Evans, Steven Narod, Henry Lynch. University of Sydney, Royal Melbourne Hospital, University of Toronto, Creighton University, Moffit Cancer Center/USF, University of Manchester, Creighton University. Preferences of Women With Inherited Mutations in the Breast and Ovarian Cancer Susceptibility Genes (BRCA1 or BRCA2) for Treatments to Prevent Breast Cancer. A Discrete Choice Experiment April 2015 339
Full project application
Jodi Saunus, Sunil Lakhani, Pete Simpson University of Queensland Centre for Clinical Research Identifying new prognostic markers and therapeutic targets in triple negative, basal-like breast cancer January 2015 269
Full project application
David Bowtell, Kath Alsop, Anna DeFazio The Peter MacCallum Cancer Centre and The Westmead Research Institute Association between germline BRCA1/2 mutation nomenclature and survival in epithelial ovarian cancer March 2015
Full project application
Jenn Stone and Christobel Saunders Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth Mammographic density in families with high-risk of breast cancer April 2015
Full application. Completed
Bettina Meiser, Ms Mary-Anne Young, David Thomas, Mandy Ballinger, Gillian Mitchell, Martin Tattersall, Judy Kirk, Sian Smith, Amanda Willis Prince of Wales Clinical School, UNSW, Sydney, Peter MacCallum Cancer Centre, Melbourne, Garvan Institute of Medical Research, Darlinghurst, , Royal Prince Alfred Hospital, Camperdown, Development and pilot testing of a decision aid for individuals notified of clinically significant genetic research findings JUne 2015
Full application, completed
Neil Johnson The Fox Chase Cancer Center, Philadelphia, USA An investigation into the expression levels of BRCA1 and BRCA2 mRNA and protein generated from germline mutant tumours. August 2015
Full application. Completed
Mark Mccabe and Anne Cormack Garvan Institute of Medical Research, NSW Validating a next generation sequencing targeted panel. August 2015
Full application, completed
Alex Swarbrick and Laura Baker Garvan Institute of Medical Research, Sydney The association between ID4 and BRCA1 September 2015
Full application
Melissa Southey and Amanda Spurdle The Univeristy of Melbourne, Melbourne and QIMR Berghofer Medical Research Institute, Brisbane BRIDGES: Breast Cancer Risk after Diagnostic Gene Sequencing September 2015
Full application
Paul Waring, Michael Christie and Diar Aziz The University of Melbourne Detection of CCNE1 gene amplification/cyclin E overexpression in breast cancer using novel assays November 2015
Full project application
Logan Walker et al Department of Pathology, University of Otago, Christchurch, New Zealand Identifying mRNA markers associated with BRCA1 and/or BRCA2 mutation status in breast cancer patients using RNA in situ hybridisation Nov 2015
Full project application
Rachel Glassey and Christobel Saunders University of Western Australia The information needs and experiences of younger women with a family history of breast cancer considering or having undergone a bilateral prophylactic mastectomy Nov 2015 325; 331; 332
Pilot project
Geoff Lindeman, Jane Visvader, Stephen Fox, Sherene Loi, Phil Darcy, Daniel Gray The Peter MacCallum Cancer Centre and The Walter and Eliza Hall Institute, Melbourne Evaluation of tumour infiltrating stromal cells in BRCA associated breast tumours. January 2016
Full application
Kelly Phillips et al. Peter MacCallum Cancer Centre Understanding The Barriers and Enablers of Uptake of Cancer Screening and Prevention Measures in Women Enrolled in kConFab. January 2016
Pilot project
Christine Hawkins and Suzanne Cutts La Trobe Institute for Molecular Science, La Trobe University, Melbourne. Modelling therapy-related cancer by testing the mutagenicity of novel anti-cancer drugs on cells with intact or perturbed DNA damage responses January 2016
Full project application
Ambry Genetics Ambry Genetics Research Relating to Lymphoblastoid Cell Lines Derived from the Blood of Patients with BRCA1/2 Variants. February 2016
Full Project. Completed
Cass Hoskins and Alison Trainor Royal Melbourne and PeterMac Family Cancer Clinics Australian Male Breast Cancer Survivors: A Needs Assessment March 2016
Full application
Salomon M Stemmer and Irit Ben-Aharon Institute of Oncology, Davidoff Center, Tel Aviv University, Tel Aviv, Israel Association of BRCA mutations with co-morbidities other than cancer March 2016
Full project application
Shahneen Sandhu et al The Peter MacCallum Cancer Centre, Melbourne Response to therapies in BRCA1 and BRCA2 carriers with Prostate Cancer. June 2016
Full application
Shahneen Sandhu, Patricia Banks The Peter MacCallum Cancer Centre, Melbourne The immune microenvironment in prostate cancer: comparison of prostate tumour samples from patients with BRCA mutation or mismatch repair deficiency to those without. October 2016
Full application
Amanda Toland et al. The Ohio State University, USA Prospective BRCA1/2 mutation carrier study October 2016
Full application
Paul Hertzog, Belinda Parker, Zoe Marks Hudson Institute of Medical Research and La Trobe Institute for Molecular Science, Melbourne Type I interferon signatures in breast cancer December 2016
Full application
Mei Sim Lung and Ian Campbell The Peter MacCallum Cancer Centre, Melbourne The search for genes that predispose to both breast and colorectal cancers by full exome sequencing. February 2017
Full project
Margaret Kelaher and Imogen Elsum Centre for Health Policy, The University of Melbourne, Melbourne. Better Indigenous Genetic (BIG) health services May 2017
Full project
Dr Mandy Spudle et al Evaluation of the clinical significance of sequence variants in known or suspected breast cancer susceptibility genes within the ENIGMA consortium framework April 2017
Full project
Liz Christie et al The Peter MacCallum Cancer Centre, Melbourne. Investigation of the role of ABCB1 in chemotherapy resistance July 2017
Full project
Shannon Fox, Margaret Kelaher, Imogen Elsum The University of Melbourne, Melbourne Factors influencing decision making around genetic health services in Indigenous Australian populations August 2017
Full project
Nicola Wolstenholme European Molecular Genetics Quality Network Application to seek access to kConFab cell lines for use in External Quality Assessment schemes (EQA) to facilitate improved patient testing for familial breast and ovarian cancer. October 2017
Full project
James Flanagan Imperial College, London Exploring mechanisms of oestrogen exposure and DNA methylation in lymphocyte cell lines October 2017
Full project
Martha Hickey and Ines Rio The Royal Melbourne Hospital, Melbourne Developing educational resources for high-risk women and health care professionals around risk reducing bilateral salpingo-oophorectomy (RRBSO) December 2017
Full project
Trans_hit Biomarkers Inc. Canada Prostate cancer and drug response January 2018
Full project
David Gallego Ortega Garvan Institute of Medical Research The Kinghorn Cancer Centre, NSW Releasing the handbrake for immunotherapies in breast cancer. March 2018
Full project
Susan Ramus School of Women’s and Children’s Health, UNSW, Sydney. Whole exome sequencing (WES) of familial non high grade serous ovarian cancer cases. June 2018
Full project
Tissue Solutions UK Tissue Solutions UK DNA screening of LGRs: validation study July 2018
Full project
Laura Forrest et al The Peter MacCallum Cancer Centre , Melbourne Why patients consent to take part in a rapid autopsy study: qualitative interviews with CASCADE participants June 2018
Full project
Kris Barlow Stewart University of Sydney Investigating Public Perceptions & Experiences on the Use of Genetic Information in Insurance June 2018
Full project
Paul Neeson, Miles Prince, Criselle D’Souza, Harini deSilva, Bruce Mann, Sophie Nightingale. The Peter MacCallum Cancer Centre , Melbourne Study of Anaplastic large cell lymphoma associated with breast implants December 2018
Full project
Mandy Spurdle et al. QIMR Berghofer Medical Research Institute, Brisbane Development of quantitative and qualitative classification models to assess clinical importance of variation in TP53 January 2019
Full project
Irmgard Irminger-Finger BARD1 Life Sciences Limited A blood test for the early detection of breast and ovarian cancer May 2019
Pilot project
Kylie Gorringe The Peter MacCallum Cancer Centre , Melbourne Single-cell RNA sequencing of frozen prophylactic salpingo-oophorectomy tissues April 2019
Full project
Doug Brooks and Jess Logan School of Pharmacy and Medical Sciences, Cancer Research Institute, University of South Australia, City West Campus I HIB, North Terrace, Adelaide SA 5000 Diagnosis and Prognosis of Prostate Cancer May 2019
Pilot application
Doug Brooks and Jess Logan School of Pharmacy and Medical Sciences, Cancer Research Institute, University of South Australia, City West Campus I HIB, North Terrace, Adelaide SA 5000 Diagnosis and Prognosis of Ovarian Cancer July 2019
Pilot application
Ashok Venkitaraman and Mona Shehata Medical Research Council Cancer Unit, Cambridge, UK Understanding the early pathogenesis of breast cancer in patients carrying BRCA2 mutations. September 2019