These sensitivity classifications allow researchers to note the level of BRCA1 and BRCA2 testing that has been performed in the non-BRCA1/2 families. In most cases only one person has been tested from a family, so the sensitivities relate to that person's tests. Where more than one person has been tested, the sensitivities relate to the most sensitive tests performed

Complete

full sequencing by Myriad, or GTG or Oefner, plus MLPA

Very High

full sequencing by Myriad, or GTG or Oefner

High + MLPA

high sensitivity screening plus MLPa

High

DHPLC, chemical cleavage, sequencing by any lab other than Myriad or GTG for all exons.

High

restriction enzyme/sequencing

High

a combination of methods (e.g. PTT/DHPLC/SEQ/MLPA of all exons)

Moderate

PTT, DGGE for all exons

Moderate

PTT for exon 11 but sequencing/DHPLC for all remaining exons

Low

e.g. SSCP, or analysis of only some of the exons by any method e.g.Jewish mutations only or predictive testing.

Low

MLPA only